| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nonstructural protein 5A |
|---|
| Ligand | BDBM50514774 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1858471 (CHEMBL4359200) |
|---|
| EC50 | 12.2±n/a nM |
|---|
| Citation |  Kazmierski, WM; Baskaran, S; Walker, JT; Miriyala, N; Meesala, R; Beesu, M; Adjabeng, G; Grimes, RM; Hamatake, R; Leivers, MR; Crosby, R; Xia, B; Remlinger, K GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage. J Med Chem63:4155-4170 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nonstructural protein 5A |
|---|
| Name: | Nonstructural protein 5A |
|---|
| Synonyms: | NS5A | Nonstructural protein 5A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 48587.20 |
|---|
| Organism: | Hepatitis C virus |
|---|
| Description: | ChEMBL_108438 |
|---|
| Residue: | 447 |
|---|
| Sequence: | SGSWLRDVWDWICTVLTDFKTWLQSKLLPRIPGVPFLSCQRGYKGVWRGDGIMHTTCPCG
AQITGHVKNGSMRIVGPKTCSNTWHGTFPINTYTTGPCTPSPAPNYSRALWRVAAEEYVE
VTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFMVGLN
QYLVGSQLPCEPEPDVTVLTSMLTDPSHITAETAGRRLARGSPPSLASSSASQLSAPSLK
ATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLQAEEDEREVSVPA
EILRKSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRT
VVLTESTVSSALAELATKTFGSSGSSAVDSGTATAPPDQLPGDGDSGSDVESYSSMPPLE
GEPGDPDLSDGSWSTMSEEASEDVVCC
|
|
|
|---|
| BDBM50514774 |
|---|
| n/a |
|---|
| Name | BDBM50514774 |
|---|
| Synonyms: | CHEMBL4444885 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C44H54N8O6 |
|---|
| Mol. Mass. | 790.9496 |
|---|
| SMILES | [H][C@]12C[C@H](N(C(=O)[C@@H](NC(=O)OC)C(C)C)[C@@]1([H])CCCC2)c1ncc([nH]1)-c1ccc2-c3cc(ccc3-c2c1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
