| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM50070787 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_208333 |
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| Ki | 160±n/a nM |
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| Citation |  Naylor-Olsen, AM; Ponticello, GS; Lewis, SD; Mulichak, AM; Chen, Z; Habecker, CN; Phillips, BT; Sanders, WM; Tucker, TJ; Shafer, JA; Vacca, JP Identification and SAR for a selective, nonpeptidyl thrombin inhibitor. Bioorg Med Chem Lett8:1697-702 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM50070787 |
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| n/a |
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| Name | BDBM50070787 |
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| Synonyms: | 4-Amino-1-[4-(1,3-diphenyl-propoxy)-benzyl]-pyridinium | CHEMBL47481 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N2O |
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| Mol. Mass. | 395.5155 |
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| SMILES | [NH2+]=c1ccn(Cc2ccc(OC(CCc3ccccc3)c3ccccc3)cc2)cc1 |
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| Structure | 
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