Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50070948 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_147139 |
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Ki | 2409±n/a nM |
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Citation | Tsai, YC; Liou, JP; Liao, R; Cheng, CY; Tao, PL C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study. Bioorg Med Chem Lett8:1813-8 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50070948 |
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n/a |
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Name | BDBM50070948 |
Synonyms: | 1',2-dimethylspiro[2,3-dihydrobenzo[b]furan-3,4'-(hexahydropyridine)]-7-ol | CHEMBL50098 |
Type | Small organic molecule |
Emp. Form. | C14H19NO2 |
Mol. Mass. | 233.3062 |
SMILES | CC1Oc2c(cccc2O)C11CCN(C)CC1 |
Structure |
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