| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuraminidase |
|---|
| Ligand | BDBM4994 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1863602 (CHEMBL4364577) |
|---|
| IC50 | 4.5±n/a nM |
|---|
| Citation |  Jia, R; Zhang, J; Ai, W; Ding, X; Desta, S; Sun, L; Sun, Z; Ma, X; Li, Z; Wang, D; Huang, B; Zhan, P; Liu, X Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase inhibitors. Eur J Med Chem178:64-80 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuraminidase |
|---|
| Name: | Neuraminidase |
|---|
| Synonyms: | NA | NRAM_I71A1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52105.18 |
|---|
| Organism: | Influenza A virus (strain A/Memphis/1/1971 H3N2) |
|---|
| Description: | ChEMBL_578382 |
|---|
| Residue: | 469 |
|---|
| Sequence: | MNPNQKIITIGSVSLTIATVCFLMQIAILVTTVTLHFKQYECDSPANNQVMPCEPIIIER
NITEIVYLTNTTIEKEICPKLVEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREP
YVSCDPGKCYQFALGQGTTLDNKHSNDTIHDRIPHRTLLMNELGVPFHLGTRQVCIAWSS
SSCHDGKAWLHVCVTGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVV
MTDGSASGRADTRILFIEEGKIVHISPLSGSAQHVEECSCYPRYPGVRCICRDNWKGSNR
PVVDINVKDYSIDSRYVCSGLVGDTPRNNDRSSNSNCRNPNNDKGNHGVKGWAFDDGNDV
WMGRTISKDSRSGYETFKVIGGWSTPNSKSQINRQVIVDSDNRSGYSGIFSVEGKSCINR
CFYVELIRGREQETRVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
|
|
|
|---|
| BDBM4994 |
|---|
| n/a |
|---|
| Name | BDBM4994 |
|---|
| Synonyms: | (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid | CHEMBL674 | GS4071 | Oseltamivir carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H24N2O4 |
|---|
| Mol. Mass. | 284.3514 |
|---|
| SMILES | CCC(CC)O[C@@H]1C=C(C[C@H](N)[C@H]1NC(C)=O)C(O)=O |r,c:7| |
|---|
| Structure | 
|
|---|
Search and Browse
