Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Ligand | BDBM50071466 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_66285 |
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EC50 | 7.4±n/a nM |
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Citation | Goulet, MT; McAlpine, SR; Staruch, MJ; Koprak, S; Dumont, FJ; Cryan, JG; Wiederrecht, GJ; Rosa, R; Wilusz, MB; Peterson, LB; Wyvratt, MJ; Parsons, WH C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential. Bioorg Med Chem Lett8:2253-8 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B |
Type: | Isomerase |
Mol. Mass.: | 11953.09 |
Organism: | Homo sapiens (Human) |
Description: | P62942 |
Residue: | 108 |
Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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BDBM50071466 |
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n/a |
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Name | BDBM50071466 |
Synonyms: | Ascomycin derivative | CHEMBL386482 |
Type | Small organic molecule |
Emp. Form. | C54H79N3O12 |
Mol. Mass. | 962.218 |
SMILES | CC[C@@H]1\C=C(C)\C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)C(\C)=C\[C@@H]1CC[C@@H](OCc2nccn2Cc2ccccc2)[C@@H](C1)OC |c:3| |
Structure |
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