| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
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| Ligand | BDBM50072055 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_158760 |
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| IC50 | 45000±n/a nM |
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| Citation |  Friesen, RW; Brideau, C; Chan, CC; Charleson, S; Deschênes, D; Dubé, D; Ethier, D; Fortin, R; Gauthier, JY; Girard, Y; Gordon, R; Greig, GM; Riendeau, D; Savoie, C; Wang, Z; Wong, E; Visco, D; Xu, LJ; Young, RN 2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett8:2777-82 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 1 |
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| Name: | Prostaglandin G/H synthase 1 |
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| Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 68692.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23219 |
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| Residue: | 599 |
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| Sequence: | MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
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| BDBM50072055 |
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| n/a |
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| Name | BDBM50072055 |
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| Synonyms: | 5-Chloro-3-(4-methanesulfonyl-phenyl)-2'-methyl-[2,3']bipyridinyl | CHEMBL96950 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15ClN2O2S |
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| Mol. Mass. | 358.842 |
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| SMILES | Cc1ncccc1-c1ncc(Cl)cc1-c1ccc(cc1)S(C)(=O)=O |
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| Structure | 
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