| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50517534 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1869141 (CHEMBL4370207) |
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| Ki | 1.1±n/a nM |
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| Citation |  Nirogi, R; Shinde, A; Mohammed, AR; Badange, RK; Reballi, V; Bandyala, TR; Saraf, SK; Bojja, K; Manchineella, S; Achanta, PK; Kandukuri, KK; Subramanian, R; Benade, V; Palacharla, RC; Jayarajan, P; Pandey, S; Jasti, V Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H J Med Chem62:1203-1217 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50517534 |
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| n/a |
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| Name | BDBM50517534 |
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| Synonyms: | CHEMBL4476066 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H38Cl2N4O4 |
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| Mol. Mass. | 517.489 |
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| SMILES | Cl.Cl.CCOC(=O)N1CCN(CC(=O)Nc2ccc(OC3CCN(CC3)C3CCC3)cc2)CC1 |
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| Structure | 
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