| Reaction Details |
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 | Report a problem with these data |
| Target | Delta-type opioid receptor |
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| Ligand | BDBM50072453 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_147165 |
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| Ki | 222±n/a nM |
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| Citation |  Thomas, JB; Mascarella, SW; Burgess, JP; Xu, H; McCullough, KB; Rothman, RB; Flippen-Anderson, JL; George, CF; Cantrell, BE; Zimmerman, DM; Carroll, FI N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists. Bioorg Med Chem Lett8:3149-52 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Delta-type opioid receptor |
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| Name: | Delta-type opioid receptor |
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| Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40382.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
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| Residue: | 372 |
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| Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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| BDBM50072453 |
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| n/a |
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| Name | BDBM50072453 |
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| Synonyms: | 3-((4aS,10aS)-2,10a-Dimethyl-1,3,4,5,10,10a-hexahydro-2H-benzo[g]isoquinolin-4a-yl)-phenol | CHEMBL324681 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25NO |
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| Mol. Mass. | 307.4293 |
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| SMILES | CN1CC[C@@]2(Cc3ccccc3C[C@]2(C)C1)c1cccc(O)c1 |
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| Structure | 
|
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