| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kinesin-like protein KIF15 |
|---|
| Ligand | BDBM50085411 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1871560 (CHEMBL4372727) |
|---|
| IC50 | 750±n/a nM |
|---|
| Citation |  Dumas, ME; Chen, GY; Kendrick, ND; Xu, G; Larsen, SD; Jana, S; Waterson, AG; Bauer, JA; Hancock, W; Sulikowski, GA; Ohi, R Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes. Bioorg Med Chem Lett29:148-154 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kinesin-like protein KIF15 |
|---|
| Name: | Kinesin-like protein KIF15 |
|---|
| Synonyms: | KIF15 | KIF15_HUMAN | KLP2 | KNSL7 | Kinesin-like protein 2 | Kinesin-like protein 7 | Kinesin-like protein KIF15 | Serologically defined breast cancer antigen NY-BR-62 | hKLP2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 160144.41 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_109919 |
|---|
| Residue: | 1388 |
|---|
| Sequence: | MAPGCKTELRSVTNGQSNQPSNEGDAIKVFVRIRPPAERSGSADGEQNLCLSVLSSTSLR
LHSNPEPKTFTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMM
GPSESDNFSHNLRGVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDS
ASAGLYLREHIKKGVFVVGAVEQVVTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVF
TITIESMEKSNEIVNIRTSLLNLVDLAGSERQKDTHAEGMRLKEAGNINRSLSCLGQVIT
ALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRA
KLIKNKAVVNEDTQGNVSQLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYMEYFQE
AMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGG
FLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMD
AQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQ
EYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKIHAETLKIIT
TPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAISEELR
TVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLN
VLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHM
HVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNFKKENETLKSDLN
NLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLE
ESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSVCEKTETIDTLKQELKDINCKYN
SALVDREESRVLIKKQEVDILDLKETLRLRILSEDIERDMLCEDLAHATEQLNMLTEASK
KHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQ
SPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEILRMKEQLRE
MENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQNHPDNQQLKNEQEESIKERLAKSKIV
EEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQLRSKLEEMYEERE
RTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAEETEKLRAENVFL
KEKKRSES
|
|
|
|---|
| BDBM50085411 |
|---|
| n/a |
|---|
| Name | BDBM50085411 |
|---|
| Synonyms: | 3-[1-(3,5-Dichloro-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-(furan-2-carbonyl)-1,3-dihydro-indol-2-one | CHEMBL73157 | GSK screening, 31 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H11Cl2NO4 |
|---|
| Mol. Mass. | 400.212 |
|---|
| SMILES | Oc1c(Cl)cc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2ccco2)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
