| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50073186 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_84704 |
|---|
| Ki | 49±n/a nM |
|---|
| Citation |  Piwinski, JJ; Wong, JK; Green, MJ; Kaminski, JJ; Colizzo, F; Albanese, MM; Ganguly, AK; Billah, MM; Anthes, JC; West, RE Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines. Bioorg Med Chem Lett8:3469-74 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | HISTAMINE H1 | HRH1_RAT | Hrh1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 55716.35 |
|---|
| Organism: | RAT |
|---|
| Description: | HISTAMINE H1 HRH1 RAT::P31390 |
|---|
| Residue: | 486 |
|---|
| Sequence: | MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKC
ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLR
SDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCF
RLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTT
DSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIM
AAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKK
ILHIRS
|
|
|
|---|
| BDBM50073186 |
|---|
| n/a |
|---|
| Name | BDBM50073186 |
|---|
| Synonyms: | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-methyl-piperazin-2-one | CHEMBL332936 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20ClN3O |
|---|
| Mol. Mass. | 341.835 |
|---|
| SMILES | CN1CCN(CC1=O)C1c2ccc(Cl)cc2CCc2cccnc12 |
|---|
| Structure | 
|
|---|
Search and Browse
