| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50073831 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101745 |
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| IC50 | 180±n/a nM |
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| Citation |  Reiter, LA; Rizzi, JP; Pandit, J; Lasut, MJ; McGahee, SM; Parikh, VD; Blake, JF; Danley, DE; Laird, ER; Lopez-Anaya, A; Lopresti-Morrow, LL; Mansour, MN; Martinelli, GJ; Mitchell, PG; Owens, BS; Pauly, TA; Reeves, LM; Schulte, GK; Yocum, SA Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket. Bioorg Med Chem Lett9:127-32 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50073831 |
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| n/a |
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| Name | BDBM50073831 |
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| Synonyms: | (4-Benzyl-benzyl)-[3-cyclobutyl-2-((R)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-propyl]-phosphinic acid | CHEMBL27439 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H41N2O4P |
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| Mol. Mass. | 512.6206 |
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| SMILES | CNC(=O)[C@H](NC(=O)C(CC1CCC1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C |
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| Structure | 
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