Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50073833 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_101745 |
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IC50 | 60±n/a nM |
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Citation | Reiter, LA; Rizzi, JP; Pandit, J; Lasut, MJ; McGahee, SM; Parikh, VD; Blake, JF; Danley, DE; Laird, ER; Lopez-Anaya, A; Lopresti-Morrow, LL; Mansour, MN; Martinelli, GJ; Mitchell, PG; Owens, BS; Pauly, TA; Reeves, LM; Schulte, GK; Yocum, SA Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket. Bioorg Med Chem Lett9:127-32 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50073833 |
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n/a |
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Name | BDBM50073833 |
Synonyms: | (4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-4-methyl-pentyl]-phosphinic acid | CHEMBL28170 |
Type | Small organic molecule |
Emp. Form. | C28H41N2O4P |
Mol. Mass. | 500.6099 |
SMILES | CNC(=O)[C@H](NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C |
Structure |
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