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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Peroxisome proliferator-activated receptor gamma | ||
| Ligand | BDBM50519887 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1878653 (CHEMBL4380047) | ||
| IC50 | >50000±n/a nM | ||
| Citation |  Meijer, FA; Doveston, RG; de Vries, RMJM; Vos, GM; Vos, AAA; Leysen, S; Scheepstra, M; Ottmann, C; Milroy, LG; Brunsveld, L Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor ?t (ROR?t) Inverse Agonists. J Med Chem63:241-259 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Peroxisome proliferator-activated receptor gamma | |||
| Name: | Peroxisome proliferator-activated receptor gamma | ||
| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 57613.46 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P37231 | ||
| Residue: | 505 | ||
| Sequence: |
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| BDBM50519887 | |||
| n/a | |||
| Name | BDBM50519887 | ||
| Synonyms: | CHEMBL4457177 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H14ClF3N2O4 | ||
| Mol. Mass. | 486.827 | ||
| SMILES | OC(=O)c1ccc(cc1)C(=O)Nc1c(noc1-c1ccccc1)-c1c(Cl)cccc1C(F)(F)F |(41.67,-9.99,;41.39,-8.48,;42.56,-7.48,;39.94,-7.97,;38.77,-8.97,;37.32,-8.46,;37.04,-6.95,;38.2,-5.95,;39.65,-6.45,;35.59,-6.44,;35.31,-4.92,;34.42,-7.44,;32.97,-6.93,;31.7,-7.81,;30.47,-6.86,;30.97,-5.41,;32.53,-5.45,;33.46,-4.23,;34.99,-4.43,;35.92,-3.21,;35.33,-1.79,;33.8,-1.59,;32.87,-2.81,;31.72,-9.39,;33.09,-10.15,;34.45,-9.34,;33.11,-11.73,;31.75,-12.54,;30.37,-11.76,;30.35,-10.19,;29.02,-9.43,;29,-7.89,;27.69,-10.21,;27.67,-8.66,)| | ||
| Structure | 
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