| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingomyelin phosphodiesterase |
|---|
| Ligand | BDBM50520397 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1880130 (CHEMBL4381524) |
|---|
| IC50 | 2110±n/a nM |
|---|
| Citation |  Yang, K; Yu, J; Nong, K; Wang, Y; Niu, A; Chen, W; Dong, J; Wang, J Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity. J Med Chem63:961-974 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingomyelin phosphodiesterase |
|---|
| Name: | Sphingomyelin phosphodiesterase |
|---|
| Synonyms: | 3.1.4.12 | ASM | ASM_HUMAN | Acid sphingomyelinase | SMPD1 | Sphingomyelin phosphodiesterase | aSMase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 69945.03 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_11570 |
|---|
| Residue: | 631 |
|---|
| Sequence: | MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAE
AHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIK
LCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISL
PTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASR
PGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTT
VTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL
RTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGD
KVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAV
AFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYR
ARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLS
ARADSPALCRHLMPDGSLPEAQSLWPRPLFC
|
|
|
|---|
| BDBM50520397 |
|---|
| n/a |
|---|
| Name | BDBM50520397 |
|---|
| Synonyms: | CHEMBL4465034 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H25NO3 |
|---|
| Mol. Mass. | 327.4174 |
|---|
| SMILES | CCCCCCc1ccc(COc2cccc(c2)C(=O)NO)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
