| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50075017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_72349 |
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| IC50 | 7.0±n/a nM |
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| Citation |  Burke, TR; Luo, J; Yao, ZJ; Gao, Y; Zhao, H; Milne, GW; Guo, R; Voigt, JH; King, CR; Yang, D Monocarboxylic-based phosphotyrosyl mimetics in the design of GRB2 SH2 domain inhibitors. Bioorg Med Chem Lett9:347-52 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50075017 |
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| n/a |
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| Name | BDBM50075017 |
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| Synonyms: | CHEMBL332862 | Phosphoric acid mono-[4-((R)-2-acetylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-phenyl] ester |
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| Type | Small organic molecule |
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| Emp. Form. | C35H44N5O9P |
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| Mol. Mass. | 709.7257 |
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| SMILES | CC(=O)N[C@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCc1cccc2ccccc12 |
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| Structure | 
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