| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Capsid scaffolding protein |
|---|
| Ligand | BDBM50075173 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_43065 |
|---|
| IC50 | 29±n/a nM |
|---|
| Citation |  Pinto, IL; Jarvest, RL; Clarke, B; Dabrowski, CE; Fenwick, A; Gorczyca, MM; Jennings, LJ; Lavery, P; Sternberg, EJ; Tew, DG; West, A Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism. Bioorg Med Chem Lett9:449-52 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Capsid scaffolding protein |
|---|
| Name: | Capsid scaffolding protein |
|---|
| Synonyms: | APNG | Assemblin | Assembly protein | Capsid protein P40 | Human cytomegalovirus protease (HCMV Pr) | Human herpes virus 5 capsid protein P40 | Protease precursor | SCAF_HCMVA | UL80 | pPR |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 73854.16 |
|---|
| Organism: | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
|---|
| Description: | ChEMBL_158958 |
|---|
| Residue: | 708 |
|---|
| Sequence: | MTMDEQQSQAVAPVYVGGFLARYDQSPDEAELLLPRDVVEHWLHAQGQGQPSLSVALPLN
INHDDTAVVGHVAAMQSVRDGLFCLGCVTSPRFLEIVRRASEKSELVSRGPVSPLQPDKV
VEFLSGSYAGLSLSSRRCDDVEAATSLSGSETTPFKHVALCSVGRRRGTLAVYGRDPEWV
TQRFPDLTAADRDGLRAQWQRCGSTAVDASGDPFRSDSYGLLGNSVDALYIRERLPKLRY
DKQLVGVTERESYVKASVSPEAACDIKAASAERSGDSRSQAATPAAGARVPSSSPSPPVE
PPSPVQPPALPASPSVLPAESPPSLSPSEPAEAASMSHPLSAAVPAATAPPGATVAGASP
AVSSLAWPHDGVYLPKDAFFSLLGASRSAVPVMYPGAVAAPPSASPAPLPLPSYPASYGA
PVVGYDQLAARHFADYVDPHYPGWGRRYEPAPSLHPSYPVPPPPSPAYYRRRDSPGGMDE
PPSGWERYDGGHRGQSQKQHRHGGSGGHNKRRKETAAASSSSSDEDLSFPGEAEHGRARK
RLKSHVNSDGGSGGHAGSNQQQQQRYDELRDAIHELKRDLFAARQSSTLLSAALPSAASS
SPTTTTVCTPTGELTSGGGETPTALLSGGAKVAERAQAGVVNASCRLATASGSEAATAGP
STAGSSSCPASVVLAAAAAQAAAASQSPPKDMVDLNRRIFVAALNKLE
|
|
|
|---|
| BDBM50075173 |
|---|
| n/a |
|---|
| Name | BDBM50075173 |
|---|
| Synonyms: | (E)-4-(3-Methoxy-phenyl)-4-oxo-but-2-enoic acid [(S)-1-(5-methyl-4-oxo-4H-thieno[2,3-d][1,3]oxazin-2-yl)-ethyl]-amide | CHEMBL140485 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18N2O5S |
|---|
| Mol. Mass. | 398.432 |
|---|
| SMILES | COc1cccc(c1)C(=O)\C=C\C(=O)N[C@@H](C)c1nc2scc(C)c2c(=O)o1 |
|---|
| Structure | 
|
|---|
Search and Browse
