| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingomyelin phosphodiesterase 3 |
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| Ligand | BDBM50521429 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1884279 (CHEMBL4385861) |
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| IC50 | 130±n/a nM |
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| Citation |  Stepanek, O; Hin, N; Thomas, AG; Dash, RP; Alt, J; Rais, R; Rojas, C; Slusher, BS; Tsukamoto, T Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. Eur J Med Chem170:276-289 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingomyelin phosphodiesterase 3 |
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| Name: | Sphingomyelin phosphodiesterase 3 |
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| Synonyms: | 3.1.4.12 | NSMA2_HUMAN | Neutral sphingomyelinase 2 | Neutral sphingomyelinase II | SMPD3 | Sphingomyelin phosphodiesterase 3 | nSMase-2 | nSMase2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71072.54 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119220 |
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| Residue: | 655 |
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| Sequence: | MVLYTTPFPNSCLSALHCVSWALIFPCYWLVDRLAASFIPTTYEKRQRADDPCCLQLLCT
ALFTPIYLALLVASLPFAFLGFLFWSPLQSARRPYIYSRLEDKGLAGGAALLSEWKGTGP
GKSFCFATANVCLLPDSLARVNNLFNTQARAKEIGQRIRNGAARPQIKIYIDSPTNTSIS
AASFSSLVSPQGGDGVARAVPGSIKRTASVEYKGDGGRHPGDEAANGPASGDPVDSSSPE
DACIVRIGGEEGGRPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRE
SLVKGRAGPDTSASGEPGANSKLLYKASVVKKAAARRRRHPDEAFDHEVSAFFPANLDFL
CLQEVFDKRAATKLKEQLHGYFEYILYDVGVYGCQGCCSFKCLNSGLLFASRYPIMDVAY
HCYPNKCNDDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPQEDSAIRCGQLDLLQ
DWLADFRKSTSSSSAANPEELVAFDVVCGDFNFDNCSSDDKLEQQHSLFTHYRDPCRLGP
GEEKPWAIGTLLDTNGLYDEDVCTPDNLQKVLESEEGRREYLAFPTSKSSGQKGRKELLK
GNGRRIDYMLHAEEGLCPDWKAEVEEFSFITQLSGLTDHLPVAMRLMVSSGEEEA
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| BDBM50521429 |
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| n/a |
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| Name | BDBM50521429 |
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| Synonyms: | CHEMBL4436316 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N2O3 |
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| Mol. Mass. | 310.3471 |
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| SMILES | COc1cc(cc(OC)c1O)-c1nc(c[nH]1)-c1ccc(C)cc1 |
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| Structure | 
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