| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50067861 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1888460 (CHEMBL4390137) |
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| IC50 | 942±n/a nM |
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| Citation |  Shah, K; Queener, S; Cody, V; Pace, J; Gangjee, A Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection. Bioorg Med Chem Lett29:1874-1880 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50067861 |
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| n/a |
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| Name | BDBM50067861 |
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| Synonyms: | CHEMBL140940 | N*6*-Methyl-N*6*-phenyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N6 |
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| Mol. Mass. | 266.3012 |
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| SMILES | CN(c1ccccc1)c1ccc2nc(N)nc(N)c2n1 |
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| Structure | 
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