| Reaction Details |
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 | Report a problem with these data |
| Target | RAF proto-oncogene serine/threonine-protein kinase |
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| Ligand | BDBM50053410 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_163344 (CHEMBL765226) |
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| IC50 | 1300±n/a nM |
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| Citation |  Liverton, NJ; Butcher, JW; Claiborne, CF; Claremon, DA; Libby, BE; Nguyen, KT; Pitzenberger, SM; Selnick, HG; Smith, GR; Tebben, A; Vacca, JP; Varga, SL; Agarwal, L; Dancheck, K; Forsyth, AJ; Fletcher, DS; Frantz, B; Hanlon, WA; Harper, CF; Hofsess, SJ; Kostura, M; Lin, J; Luell, S; O'Neill, EA; O'Keefe, SJ Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase. J Med Chem42:2180-90 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAF proto-oncogene serine/threonine-protein kinase |
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| Name: | RAF proto-oncogene serine/threonine-protein kinase |
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| Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 73082.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P04049 |
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| Residue: | 648 |
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| Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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| BDBM50053410 |
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| n/a |
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| Name | BDBM50053410 |
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| Synonyms: | 4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole | 4-[5-(4-Fluoro-phenyl)-3H-imidazol-4-yl]-pyridine | CHEMBL63135 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10FN3 |
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| Mol. Mass. | 239.2477 |
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| SMILES | Fc1ccc(cc1)-c1[nH]cnc1-c1ccncc1 |
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| Structure | 
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