BindingDB PrimarySearch

Found 104 hits with Last Name = 'fletcher' and Initial = 'ds'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neutrophil elastase (Homo sapiens (Human))	BDBM50281051 ((2S,5R,6S)-6-Ethoxy-3,3-dimethyl-4,4,7-trioxo-4lam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrate				Bioorg Med Chem Lett 3: 2289-2294 (1993) Article DOI: 10.1016/S0960-894X(01)80941-0 BindingDB Entry DOI: 10.7270/Q2NC614S
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50281052 ((2S,5R,6S)-3,3-Dimethyl-4,7-dioxo-6-(2,2,2-trifluo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrate				Bioorg Med Chem Lett 3: 2289-2294 (1993) Article DOI: 10.1016/S0960-894X(01)80941-0 BindingDB Entry DOI: 10.7270/Q2NC614S
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50281055 (CHEMBL73926 \| {[(2S,5R,6S)-3,3-Dimethyl-4,4,7-trio...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrate				Bioorg Med Chem Lett 3: 2289-2294 (1993) Article DOI: 10.1016/S0960-894X(01)80941-0 BindingDB Entry DOI: 10.7270/Q2NC614S
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50281054 ((R)-1-[(2S,5R,6R)-3,3-Dimethyl-4,4,7-trioxo-6-(2,2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrate				Bioorg Med Chem Lett 3: 2289-2294 (1993) Article DOI: 10.1016/S0960-894X(01)80941-0 BindingDB Entry DOI: 10.7270/Q2NC614S
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50281056 (CHEMBL307622 \| {[(2S,5R,6R)-3,3-Dimethyl-4,4,7-tri...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrate				Bioorg Med Chem Lett 3: 2289-2294 (1993) Article DOI: 10.1016/S0960-894X(01)80941-0 BindingDB Entry DOI: 10.7270/Q2NC614S
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50031664 (4-((2R,3R)-1-Benzylcarbamoyl-3-methyl-4-oxo-3-prop...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Compound was evaluated in vitro for the human leukocyte elastase (HLE) inhibition, and the Kobs[I] is the second-order rate constant for the time dep...				J Med Chem 38: 2449-62 (1995) BindingDB Entry DOI: 10.7270/Q24B30BX
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50281053 (CHEMBL430991 \| [((2S,5R,6S)-6-Methoxy-3,3-dimethyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article	5.30E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested in vitro for its inhibitory effect against Elastase using Suc-Ala--Ala-Pro-Ala-pNA as substrate				Bioorg Med Chem Lett 3: 2289-2294 (1993) Article DOI: 10.1016/S0960-894X(01)80941-0 BindingDB Entry DOI: 10.7270/Q2NC614S
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50164777 ((4R,4aR,7aR)-4-Methyl-octahydro-[1]pyrindin-(2E)-y...) Show SMILES C[C@@H]1CC(N)=N[C@@H]2CCC[C@H]12 \|c:4\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Inducible nitric oxide synthase (iNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50164777 ((4R,4aR,7aR)-4-Methyl-octahydro-[1]pyrindin-(2E)-y...) Show SMILES C[C@@H]1CC(N)=N[C@@H]2CCC[C@H]12 \|c:4\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Inducible nitric oxide synthase (iNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50062133 (4-Methyl-piperidin-(2E)-ylideneamine \| 4-Methyl-pi...) Show SMILES CC1CCN=C(N)C1 \|t:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077960 (4-[5-(3,4-Dichloro-phenyl)-2-phenyl-3H-imidazol-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50164782 ((4R,4aR,5R)-4-Methyl-octahydro-quinolin-(2E)-ylide...) Show SMILES C[C@@H]1CC(N)=N[C@@H]2CCCC[C@H]12 \|c:4\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Inducible nitric oxide synthase (iNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077961 (3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50077957 (4-[2-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50164777 ((4R,4aR,7aR)-4-Methyl-octahydro-[1]pyrindin-(2E)-y...) Show SMILES C[C@@H]1CC(N)=N[C@@H]2CCC[C@H]12 \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50164777 ((4R,4aR,7aR)-4-Methyl-octahydro-[1]pyrindin-(2E)-y...) Show SMILES C[C@@H]1CC(N)=N[C@@H]2CCC[C@H]12 \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50164784 ((4S,7S)-4-Methyl-octahydro-[1]pyrindin-(2E)-yliden...) Show SMILES C[C@H]1CC(N)=N[C@H]2CCC[C@@H]12 \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50062133 (4-Methyl-piperidin-(2E)-ylideneamine \| 4-Methyl-pi...) Show SMILES CC1CCN=C(N)C1 \|t:4\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Inducible nitric oxide synthase (iNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50164779 ((4R,4aS,5S)-4-Methyl-octahydro-quinolin-(2E)-ylide...) Show SMILES C[C@@H]1CC(N)=N[C@H]2CCCC[C@@H]12 \|c:4\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Inducible nitric oxide synthase (iNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50164782 ((4R,4aR,5R)-4-Methyl-octahydro-quinolin-(2E)-ylide...) Show SMILES C[C@@H]1CC(N)=N[C@@H]2CCCC[C@H]12 \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077974 (4-(4-(4-chlorophenyl)-2-phenyl-1H-imidazol-5-yl)py...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077958 (4-[5-(4-Fluoro-phenyl)-2-piperidin-4-yl-3H-imidazo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077964 (4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-benzo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50237712 (4-(4-(3-chlorophenyl)-2-phenyl-1H-imidazol-5-yl)py...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50077951 (CHEMBL68572 \| [4-(2,5-Diphenyl-3H-imidazol-4-yl)-p...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077979 (4-[5-(4-Fluoro-phenyl)-2-piperidin-3-yl-3H-imidazo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50077963 (4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyridine \| CHEMB...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50164784 ((4S,7S)-4-Methyl-octahydro-[1]pyrindin-(2E)-yliden...) Show SMILES C[C@H]1CC(N)=N[C@H]2CCC[C@@H]12 \|c:4\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	133	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Inducible nitric oxide synthase (iNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077957 (4-[2-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50077979 (4-[5-(4-Fluoro-phenyl)-2-piperidin-3-yl-3H-imidazo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50062133 (4-Methyl-piperidin-(2E)-ylideneamine \| 4-Methyl-pi...) Show SMILES CC1CCN=C(N)C1 \|t:4\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	146	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Endothelial nitric oxide synthase (eNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50077977 (4-(2,4-diphenyl-1H-imidazol-5-yl)-N-methylpyrimidi...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	175	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50077962 (4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyrimidin-2-ylam...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50164781 ((5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine \| C...) Show SMILES NC1=N[C@H]2CCCC[C@H]2CC1 \|t:1\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	186	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Inducible nitric oxide synthase (iNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50164779 ((4R,4aS,5S)-4-Methyl-octahydro-quinolin-(2E)-ylide...) Show SMILES C[C@@H]1CC(N)=N[C@H]2CCCC[C@@H]12 \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50053410 (4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole \|...) Show SMILES Fc1ccc(cc1)-c1[nH]cnc1-c1ccncc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50077958 (4-[5-(4-Fluoro-phenyl)-2-piperidin-4-yl-3H-imidazo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077967 (4-(4-(3-methoxyphenyl)-2-phenyl-1H-imidazol-5-yl)p...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50164780 (4-Methyl-3,4-dihydro-1H-quinolin-(2E)-ylideneamine...) Show SMILES CC1CC(N)=Nc2ccccc12 \|c:4\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50049255 (CHEMBL269058 \| PIPERIDIN-2-IMINE \| Piperidin-(2E)-...) Show SMILES NC1=NCCCC1 \|t:1\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50164781 ((5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine \| C...) Show SMILES NC1=N[C@H]2CCCC[C@H]2CC1 \|t:1\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	246	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase (nNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM13336 (4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50077969 (((R)-1-Phenyl-ethyl)-{4-[2-piperidin-4-yl-5-(3-tri...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	295	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 9 (Homo sapiens (Human))	BDBM50077953 (4-(1-methyl-2-(piperidin-4-yl)-4-(3-(trifluorometh...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of c-Jun N-terminal kinase 2-alpha 1				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50049255 (CHEMBL269058 \| PIPERIDIN-2-IMINE \| Piperidin-(2E)-...) Show SMILES NC1=NCCCC1 \|t:1\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Inducible nitric oxide synthase (iNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077959 (4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-benzo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human c-Raf kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM13336 (4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human c-Raf kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077963 (4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyridine \| CHEMB...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50077976 (4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinase				J Med Chem 42: 2180-90 (1999) Article DOI: 10.1021/jm9805236 BindingDB Entry DOI: 10.7270/Q2Q81C8D
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50164777 ((4R,4aR,7aR)-4-Methyl-octahydro-[1]pyrindin-(2E)-y...) Show SMILES C[C@@H]1CC(N)=N[C@@H]2CCC[C@H]12 \|c:4\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human Endothelial nitric oxide synthase (eNOS)				Bioorg Med Chem Lett 15: 1997-2001 (2005) Article DOI: 10.1016/j.bmcl.2005.02.067 BindingDB Entry DOI: 10.7270/Q2XK8F3M
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

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