Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50281052 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_64137 |
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Ki | 1500±n/a nM |
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Citation | Thompson, KR; Finke, PE; Shah, SK; Ashe, BM; Dahlgren, ME; Dellea, PS; Fletcher, DS; Hand, KM; Maycock, AL; Doherty, JB Inhibition of human leukocyte elastase. 7. Inhibition by 6-substituted penicillin amides. Bioorg Med Chem Lett3:2289-2294 (1993) Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50281052 |
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n/a |
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Name | BDBM50281052 |
Synonyms: | (2S,5R,6S)-3,3-Dimethyl-4,7-dioxo-6-(2,2,2-trifluoro-acetylamino)-4lambda*4*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-carboxy-benzyl ester | CHEMBL306565 |
Type | Small organic molecule |
Emp. Form. | C18H17F3N2O7S |
Mol. Mass. | 462.397 |
SMILES | CC1(C)[C@@H](N2[C@@H]([C@@H](NC(=O)C(F)(F)F)C2=O)S1=O)C(=O)OCc1ccc(cc1)C(O)=O |
Structure |
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