Reaction Details |
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Target | UDP-glucuronosyltransferase 1A1 |
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Ligand | BDBM50523559 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1890697 (CHEMBL4392451) |
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IC50 | 2800±n/a nM |
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Citation | A M Subbaiah, M; Mandlekar, S; Desikan, S; Ramar, T; Subramani, L; Annadurai, M; Desai, SD; Sinha, S; Jenkins, SM; Krystal, MR; Subramanian, M; Sridhar, S; Padmanabhan, S; Bhutani, P; Arla, R; Singh, S; Sinha, J; Thakur, M; Kadow, JF; Meanwell, NA Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir. J Med Chem62:3553-3574 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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UDP-glucuronosyltransferase 1A1 |
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Name: | UDP-glucuronosyltransferase 1A1 |
Synonyms: | Bilirubin-specific UDPGT isozyme 1 | GNT1 | UD11_HUMAN | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1 | hUG-BR1 |
Type: | Enzyme |
Mol. Mass.: | 59604.34 |
Organism: | Homo sapiens (Human) |
Description: | P22309 |
Residue: | 533 |
Sequence: | MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
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BDBM50523559 |
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n/a |
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Name | BDBM50523559 |
Synonyms: | CHEMBL4573907 |
Type | Small organic molecule |
Emp. Form. | C47H61N7O8 |
Mol. Mass. | 852.0293 |
SMILES | COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@H](CN(Cc1ccc(cc1)-c1ccccn1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)OC(=O)[C@@H](N)Cc1ccccc1)C(C)(C)C |r| |
Structure |
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