| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 1A |
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| Ligand | BDBM50524610 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1894113 (CHEMBL4396034) |
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| IC50 | >10000±n/a nM |
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| Citation |  Liu, HM; Suo, FZ; Li, XB; You, YH; Lv, CT; Zheng, CX; Zhang, GC; Liu, YJ; Kang, WT; Zheng, YC; Xu, HW Discovery and synthesis of novel indole derivatives-containing 3-methylenedihydrofuran-2(3H)-one as irreversible LSD1 inhibitors. Eur J Med Chem175:357-372 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 1A |
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| Name: | Lysine-specific histone demethylase 1A |
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| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 92901.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60341 |
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| Residue: | 852 |
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| Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
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| BDBM50524610 |
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| n/a |
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| Name | BDBM50524610 |
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| Synonyms: | CHEMBL4459346 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20ClNO4 |
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| Mol. Mass. | 397.852 |
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| SMILES | COc1cccc2n(Cc3ccc(Cl)cc3)cc(C(O)C3COC(=O)C3=C)c12 |
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| Structure | 
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