Ki Summary

Reaction Details

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Target

Nuclear receptor subfamily 4 group A member 1

Ligand

BDBM50524694

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1894490 (CHEMBL4396411)

520±n/a nM

Citation

Chen, Z; Zhang, D; Yan, S; Hu, C; Huang, Z; Li, Z; Peng, S; Li, X; Zhu, Y; Yu, H; Lian, B; Kang, Q; Li, M; Zeng, Z; Zhang, XK; Su, Y SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem177:171-187 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Nuclear receptor subfamily 4 group A member 1

Name:

Nuclear receptor subfamily 4 group A member 1

Synonyms:

GFRP1 | HMR | NAK1 | NR4A1 | NR4A1_HUMAN | nuclear receptor subfamily 4, group A, member 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

64467.13

Organism:

Homo sapiens (Human)

Description:

gi_27894344

Residue:

598

Sequence:

MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPV
DEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKA
SGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAK
YICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDAS
PANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFG
DWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVA
AVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF

BDBM50524694

n/a

Name

BDBM50524694

Synonyms:

CHEMBL3892041

Type

Small organic molecule

Emp. Form.

C32H44O4

Mol. Mass.

492.6894

SMILES

[H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)OC(C)C |r,c:24,t:14,16,19|

Structure