| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 1 |
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| Ligand | BDBM50079763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209264 |
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| IC50 | 3200±n/a nM |
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| Citation |  Ahn, HS; Arik, L; Boykow, G; Burnett, DA; Caplen, MA; Czarniecki, M; Domalski, MS; Foster, C; Manna, M; Stamford, AW; Wu, Y Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists. Bioorg Med Chem Lett9:2073-8 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Proteinase-activated receptor 1 |
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| Name: | Proteinase-activated receptor 1 |
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| Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
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| Type: | Protein |
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| Mol. Mass.: | 47450.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25116 |
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| Residue: | 425 |
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| Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
|
|
|
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| BDBM50079763 |
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| n/a |
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| Name | BDBM50079763 |
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| Synonyms: | 7-(4-Isopropyl-benzyl)-N*1*,N*3*,N*3*-trimethyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL303084 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27N5 |
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| Mol. Mass. | 373.494 |
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| SMILES | CNc1nc(nc2ccc3n(Cc4ccc(cc4)C(C)C)ccc3c12)N(C)C |
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| Structure | 
|
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