| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
|---|
| Ligand | BDBM13041 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_152390 (CHEMBL765513) |
|---|
| Ki | 1600±n/a nM |
|---|
| Citation |  Grunewald, GL; Caldwell, TM; Li, Q; Slavica, M; Criscione, KR; Borchardt, RT; Wang, W Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. J Med Chem42:3588-601 (1999) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phenylethanolamine N-methyltransferase |
|---|
| Name: | Phenylethanolamine N-methyltransferase |
|---|
| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 30916.97 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | n/a |
|---|
| Residue: | 283 |
|---|
| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
|
|
|
|---|
| BDBM13041 |
|---|
| n/a |
|---|
| Name | BDBM13041 |
|---|
| Synonyms: | 3-(fluoromethyl)-7-methanesulfonyl-1,2,3,4-tetrahydroisoquinoline | 7-sulfonyl-THIQ 31 | CHEMBL333578 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H14FNO2S |
|---|
| Mol. Mass. | 243.298 |
|---|
| SMILES | CS(=O)(=O)c1ccc2CC(CF)NCc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
