| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C iota type |
|---|
| Ligand | BDBM50526582 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1900248 (CHEMBL4402363) |
|---|
| IC50 | 340±n/a nM |
|---|
| Citation |  Kwiatkowski, J; Baburajendran, N; Poulsen, A; Liu, B; Tee, DHY; Wong, YX; Poh, ZY; Ong, EH; Dinie, N; Cherian, J; Jansson, AE; Hill, J; Keller, TH; Hung, AW Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. ACS Med Chem Lett10:318-323 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C iota type |
|---|
| Name: | Protein kinase C iota type |
|---|
| Synonyms: | Atypical protein kinase C-lambda/iota | DXS1179E | KPCI_HUMAN | PRKC-lambda/iota | PRKCI | Protein kinase C (PKC) | Protein kinase C iota | Protein kinase C iota (PKCι) | Protein kinase C iota type | Protein kinase C iota type/zeta type | aPKC-lambda/iota | nPKC-iota |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68251.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41743 |
|---|
| Residue: | 596 |
|---|
| Sequence: | MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF
DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE
DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK
KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR
ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ
TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA
EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI
APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR
IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK
PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV
|
|
|
|---|
| BDBM50526582 |
|---|
| n/a |
|---|
| Name | BDBM50526582 |
|---|
| Synonyms: | CHEMBL4471416 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H22N6O |
|---|
| Mol. Mass. | 374.439 |
|---|
| SMILES | Nc1ncc(cc1C(=O)Nc1ccncc1)-c1cccc(c1)N1CCNCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
