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TargetInterstitial collagenase
LigandBDBM50081864
Substrate/Competitorn/a
Meas. Tech.ChEBML_101750
IC50 6±n/a nM
Citation Martin, FM; Beckett, RP; Bellamy, CL; Courtney, PF; Davies, SJ; Drummond, AH; Dodd, R; Pratt, LM; Patel, SR; Ricketts, ML; Todd, RS; Tuffnell, AR; Ward, JW; Whittaker, M The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors. Bioorg Med Chem Lett9:2887-92 (1999) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Interstitial collagenase
Name:Interstitial collagenase
Synonyms:CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:Enzyme
Mol. Mass.:54010.26
Organism:Homo sapiens (Human)
Description: P03956
Residue:469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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  Blast E-value cutoff:
BDBM50081864
n/a
NameBDBM50081864
Synonyms:(2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-methylmethan-2-ylsulfonamido)methyl)-4-oxo-4-(piperidin-1-yl)butanamide | (2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-methylmethylsulfonamido)methyl)-4-oxo-4-(piperidin-1-yl)butanamide | (2R,3R)-3-Cyclopentylmethyl-N-hydroxy-2-[(methanesulfonyl-methyl-amino)-methyl]-4-oxo-4-piperidin-1-yl-butyramide | CHEMBL98044
TypeSmall organic molecule
Emp. Form.C18H33N3O5S
Mol. Mass.403.537
SMILESCN(C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO)S(C)(=O)=O |r|
Structure
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