Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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Ligand | BDBM50527525 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1902812 (CHEMBL4405034) |
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Ki | 0.512861±n/a nM |
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Citation | Salado, IG; Singh, AK; Moreno-Cinos, C; Sakaine, G; Siderius, M; Van der Veken, P; Matheeussen, A; van der Meer, T; Sadek, P; Gul, S; Maes, L; Sterk, GJ; Leurs, R; Brown, D; Augustyns, K Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds. J Med Chem63:3485-3507 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase 4D |
Type: | Protein |
Mol. Mass.: | 91092.69 |
Organism: | Homo sapiens (Human) |
Description: | Q08499 |
Residue: | 809 |
Sequence: | MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA
MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP
MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL
TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF
KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL
LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC
DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP
DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL
DEQVEEEAVGEEEESQPEACVIDDRSPDT
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BDBM50527525 |
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n/a |
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Name | BDBM50527525 |
Synonyms: | CHEMBL4522249 |
Type | Small organic molecule |
Emp. Form. | C25H30N6O3 |
Mol. Mass. | 462.5441 |
SMILES | [H][C@@]12CC=CC[C@]1([H])C(=NN(C1CCN(CC1)c1ccnc(N)n1)C2=O)c1ccc(OC)c(OC)c1 |r,c:3,9| |
Structure |
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