| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| Ligand | BDBM50527939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1904112 (CHEMBL4406334) |
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| IC50 | 25000±n/a nM |
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| Citation |  Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Discovery and Structure-Activity Relationship Study of ( J Med Chem63:4880-4895 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta |
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| Synonyms: | PI42B_HUMAN | PIP4K2B | PIP5K2B | Phosphatidylinositol-5-phosphate 4-kinase type-2 beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47382.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774395 |
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| Residue: | 416 |
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| Sequence: | MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNV
PVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNS
VTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLL
PQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKD
NDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEE
RAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKK
EVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
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| BDBM50527939 |
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| n/a |
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| Name | BDBM50527939 |
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| Synonyms: | CHEMBL4436057 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15N5O3S2 |
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| Mol. Mass. | 389.452 |
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| SMILES | CS(=O)(=O)Nc1ccc(cc1)-c1cnc(N)c(\C=C2/SC(=N)NC2=O)c1 |
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| Structure | 
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