| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-5 |
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| Ligand | BDBM50099829 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1909302 (CHEMBL4411748) |
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| IC50 | 3620±n/a nM |
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| Citation |  Johnson, HWB; Lowe, E; Anderl, JL; Fan, A; Muchamuel, T; Bowers, S; Moebius, DC; Kirk, C; McMinn, DL Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem61:11127-11143 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-5 |
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| Name: | Proteasome subunit beta type-5 |
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| Synonyms: | 20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X |
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| Type: | Protein |
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| Mol. Mass.: | 28480.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 263 |
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| Sequence: | MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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| BDBM50099829 |
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| n/a |
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| Name | BDBM50099829 |
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| Synonyms: | CHEMBL3319584 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H39N3O6 |
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| Mol. Mass. | 609.7114 |
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| SMILES | COc1ccc(C[C@H](NC(=O)[C@@H](C)NC(=O)C2=C(C)c3ccccc3C2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1 |r,c:16| |
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| Structure | 
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