Reaction Details |
| Report a problem with these data |
Target | Proteasome subunit beta type-10 |
---|
Ligand | BDBM50526813 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1909305 (CHEMBL4411751) |
---|
IC50 | 97±n/a nM |
---|
Citation | Johnson, HWB; Lowe, E; Anderl, JL; Fan, A; Muchamuel, T; Bowers, S; Moebius, DC; Kirk, C; McMinn, DL Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem61:11127-11143 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Proteasome subunit beta type-10 |
---|
Name: | Proteasome subunit beta type-10 |
Synonyms: | LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i |
Type: | PROTEIN |
Mol. Mass.: | 28940.51 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_106197 |
Residue: | 273 |
Sequence: | MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRAT
NDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTR
ILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDR
FQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGR
YHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
|
|
|
BDBM50526813 |
---|
n/a |
---|
Name | BDBM50526813 |
Synonyms: | CHEMBL4465456 |
Type | Small organic molecule |
Emp. Form. | C35H48N4O5 |
Mol. Mass. | 604.7794 |
SMILES | CC(C)C[C@H](NC(=O)CN1CCCCCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r| |
Structure |
|