Reaction Details |
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Target | Proteasome subunit beta type-5 |
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Ligand | BDBM50099829 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1909308 (CHEMBL4411754) |
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IC50 | 2340±n/a nM |
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Citation | Johnson, HWB; Lowe, E; Anderl, JL; Fan, A; Muchamuel, T; Bowers, S; Moebius, DC; Kirk, C; McMinn, DL Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide). J Med Chem61:11127-11143 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proteasome subunit beta type-5 |
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Name: | Proteasome subunit beta type-5 |
Synonyms: | 3.4.25.1 | Macropain epsilon chain | Multicatalytic endopeptidase complex epsilon chain | PSB5_MOUSE | Proteasome chain 6 | Proteasome epsilon chain | Proteasome subunit X | Proteasome subunit beta type-5 | Psmb5 |
Type: | PROTEIN |
Mol. Mass.: | 28533.60 |
Organism: | Mus musculus |
Description: | ChEMBL_104444 |
Residue: | 264 |
Sequence: | MALASVLQRPMPVNQHGFFGLGGGADLLDLGPGSPGDGLSLAAPSWGVPEEPRIEMLHGT
TTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHDKYSSVSVP
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BDBM50099829 |
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n/a |
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Name | BDBM50099829 |
Synonyms: | CHEMBL3319584 |
Type | Small organic molecule |
Emp. Form. | C36H39N3O6 |
Mol. Mass. | 609.7114 |
SMILES | COc1ccc(C[C@H](NC(=O)[C@@H](C)NC(=O)C2=C(C)c3ccccc3C2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1 |r,c:16| |
Structure |
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