| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Ligand | BDBM50529843 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1910274 (CHEMBL4412720) |
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| IC50 | 740±n/a nM |
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| Citation |  Li, Y; Huang, T; Lou, B; Ye, D; Qi, X; Li, X; Hu, S; Ding, T; Chen, Y; Cao, Y; Mo, M; Dong, J; Wei, M; Chu, Y; Li, H; Jiang, XC; Cheng, N; Zhou, L Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem163:864-882 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 2 |
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| Synonyms: | SGMS2 | SMS2 | SMS2_HUMAN | Sphingomyelin synthase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42294.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108027 |
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| Residue: | 365 |
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| Sequence: | MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYI
QIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDY
IDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLP
VPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFI
KEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNL
KVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGED
NEKST
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| BDBM50529843 |
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| n/a |
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| Name | BDBM50529843 |
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| Synonyms: | CHEMBL4462317 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14ClFN2O2 |
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| Mol. Mass. | 356.778 |
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| SMILES | Fc1ccc(Cl)c(COc2ccccc2C(=O)Nc2cccnc2)c1 |
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| Structure | 
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