| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50239940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1911268 (CHEMBL4413714) |
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| EC50 | 44±n/a nM |
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| Citation |  Mengshetti, S; Zhou, L; Sari, O; De Schutter, C; Zhang, H; Cho, JH; Tao, S; Bassit, LC; Verma, K; Domaoal, RA; Ehteshami, M; Jiang, Y; Ovadia, R; Kasthuri, M; Ollinger Russell, O; McBrayer, T; Whitaker, T; Pattassery, J; Pascual, ML; Uher, L; Lin, BY; Lee, S; Amblard, F; Coats, SJ; Schinazi, RF Discovery of a Series of 2'-?-Fluoro,2'-?-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus. J Med Chem62:1859-1874 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50239940 |
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| n/a |
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| Name | BDBM50239940 |
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| Synonyms: | CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sovaldi |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29FN3O9P |
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| Mol. Mass. | 529.4525 |
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| SMILES | CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1 |r| |
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| Structure | 
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