Reaction Details |
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Target | DNA polymerase beta |
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Ligand | BDBM50164644 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1911310 (CHEMBL4413756) |
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IC50 | 8400±n/a nM |
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Citation | Mengshetti, S; Zhou, L; Sari, O; De Schutter, C; Zhang, H; Cho, JH; Tao, S; Bassit, LC; Verma, K; Domaoal, RA; Ehteshami, M; Jiang, Y; Ovadia, R; Kasthuri, M; Ollinger Russell, O; McBrayer, T; Whitaker, T; Pattassery, J; Pascual, ML; Uher, L; Lin, BY; Lee, S; Amblard, F; Coats, SJ; Schinazi, RF Discovery of a Series of 2'-?-Fluoro,2'-?-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus. J Med Chem62:1859-1874 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA polymerase beta |
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Name: | DNA polymerase beta |
Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
Type: | Protein |
Mol. Mass.: | 38188.76 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 335 |
Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
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BDBM50164644 |
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n/a |
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Name | BDBM50164644 |
Synonyms: | 2',3'-Dideoxyadenosine Triphosphate (Ddatp) | 2',3'-dideoxyadenosine triphosphate | ATP,2',3'-dideoxy | CHEMBL1383 | [[[5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid | ddA-TP | ddATP |
Type | Small organic molecule |
Emp. Form. | C10H16N5O11P3 |
Mol. Mass. | 475.1822 |
SMILES | Nc1ncnc2n(cnc12)[C@H]1CC[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 |r| |
Structure |
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