| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen-related receptor gamma |
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| Ligand | BDBM50530060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1911364 (CHEMBL4413810) |
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| IC50 | 20±n/a nM |
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| Citation |  Kim, J; Song, J; Ji, HD; Yoo, EK; Lee, JE; Lee, SB; Oh, JM; Lee, S; Hwang, JS; Yoon, H; Kim, DS; Lee, SJ; Jeong, M; Lee, S; Kim, KH; Choi, HS; Lee, SW; Park, KG; Lee, IK; Kim, SH; Hwang, H; Jeon, YH; Chin, J; Cho, SJ Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-? Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer. J Med Chem62:1837-1858 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen-related receptor gamma |
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| Name: | Estrogen-related receptor gamma |
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| Synonyms: | ERR gamma-2 | ERR3 | ERR3_HUMAN | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-Related Receptor, gamma | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51305.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1501351 |
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| Residue: | 458 |
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| Sequence: | MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGG
SSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYML
NSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSC
QACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSH
LLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL
LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMK
LEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT
LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
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| BDBM50530060 |
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| n/a |
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| Name | BDBM50530060 |
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| Synonyms: | CHEMBL4451327 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38Cl2N2O2 |
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| Mol. Mass. | 529.541 |
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| SMILES | Cl.Cl.CC(C)N1CCN(CC1)c1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1cccc(O)c1 |
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| Structure | 
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