| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50085869 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_72360 (CHEMBL686597) |
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| IC50 | 2±n/a nM |
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| Citation |  Gao, Y; Luo, J; Yao, ZJ; Guo, R; Zou, H; Kelley, J; Voigt, JH; Yang, D; Burke, TR Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic. J Med Chem43:911-20 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50085869 |
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| n/a |
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| Name | BDBM50085869 |
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| Synonyms: | CHEMBL367037 | N-[1-(1-{2-Carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-2-(4-phosphonomethyl-phenyl)-ethyl]-oxalamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C35H45N6O10P |
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| Mol. Mass. | 740.7398 |
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| SMILES | Cc1ccc2n(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C3(CCCCC3)NC(=O)[C@H](Cc3ccc(CP(O)(O)=O)cc3)NC(=O)C(O)=O)ccc2c1 |
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| Structure | 
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