| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
|---|
| Ligand | BDBM50073909 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_72360 (CHEMBL686597) |
|---|
| IC50 | 4±n/a nM |
|---|
| Citation |  Gao, Y; Luo, J; Yao, ZJ; Guo, R; Zou, H; Kelley, J; Voigt, JH; Yang, D; Burke, TR Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic. J Med Chem43:911-20 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Growth factor receptor-bound protein 2 |
|---|
| Name: | Growth factor receptor-bound protein 2 |
|---|
| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 25205.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P62993 |
|---|
| Residue: | 217 |
|---|
| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
|
|
|
|---|
| BDBM50073909 |
|---|
| n/a |
|---|
| Name | BDBM50073909 |
|---|
| Synonyms: | CHEMBL72036 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid | {4-[2-Acetylamino-2-(1-{2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H47N6O8P |
|---|
| Mol. Mass. | 710.7568 |
|---|
| SMILES | CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCn1ccc2cc(C)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
