| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cGMP-dependent protein kinase |
|---|
| Ligand | BDBM50467123 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1913587 (CHEMBL4416170) |
|---|
| IC50 | 2.0±n/a nM |
|---|
| Citation |  Matralis, AN; Malik, A; Penzo, M; Moreno, I; Almela, MJ; Camino, I; Crespo, B; Saadeddin, A; Ghidelli-Disse, S; Rueda, L; Calderon, F; Osborne, SA; Drewes, G; Böesche, M; Fernández-Álvaro, E; Martin Hernando, JI; Baker, DA Development of Chemical Entities Endowed with Potent Fast-Killing Properties against J Med Chem62:9217-9235 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cGMP-dependent protein kinase |
|---|
| Name: | cGMP-dependent protein kinase |
|---|
| Synonyms: | n/a |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 97679.99 |
|---|
| Organism: | Plasmodium falciparum |
|---|
| Description: | ChEMBL_862297 |
|---|
| Residue: | 853 |
|---|
| Sequence: | MEEDDNLKKGNERNKKKAIFSNDDFTGEDSLMEDHLELREKLSEDIDMIKTSLKNNLVCS
TLNDNEILTLSNYMQFFVFKSGNLVIKQGEKGSYFFIINSGKFDVYVNDKKVKTMGKGSS
FGEAALIHNTQRSATIIAETDGTLWGVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDML
TEAQKNMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYINDEEIRVLEKGSYFG
ERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFKQFS
GDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVELFLDDTSIGILSRGMSFG
DQYVLNQKQPFKHTIKSLEVCKIALITETCLADCLGNNNIDASIDYNNKKSIIKKMYIFR
YLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNKKRLRTLGKNDY
FGERALLYDEPRTASVISKVNNVECWFVDKSVFLQIIQGPMLAHLEERIKMQDTKVEMDE
LETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPF
IIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNI
VYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKGYGCTVDIW
ALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKRLLCRLPQG
RIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDIDIKQIEEEDAEDDE
EPLNDEDNWDIDF
|
|
|
|---|
| BDBM50467123 |
|---|
| n/a |
|---|
| Name | BDBM50467123 |
|---|
| Synonyms: | CHEMBL4288103 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H32FN7S |
|---|
| Mol. Mass. | 529.675 |
|---|
| SMILES | CN1CCC(CC1)c1nc(c(s1)-c1ccnc(Nc2ccc(cc2)N2CCNCC2)n1)-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
