| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50087419 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_90867 (CHEMBL872965) |
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| IC50 | 1700±n/a nM |
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| Citation |  Zouhiri, F; Mouscadet, JF; Mekouar, K; Desmaële, D; Savouré, D; Leh, H; Subra, F; Le Bret, M; Auclair, C; d'Angelo, J Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture. J Med Chem43:1533-40 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50087419 |
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| n/a |
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| Name | BDBM50087419 |
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| Synonyms: | (E)-2-(3,4-dihydroxy-5-methoxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-(3,4-dihydroxy-5-methoxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-[2-((E)-3,4-Dihydroxy-5-methoxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | 2-[2-(3,4-Dihydroxy-5-methoxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | CHEMBL36640 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15NO6 |
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| Mol. Mass. | 353.3255 |
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| SMILES | COc1cc(\C=C\c2ccc3ccc(C(O)=O)c(O)c3n2)cc(O)c1O |
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| Structure | 
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