| Reaction Details |
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 | Report a problem with these data |
| Target | Transcription factor ETV6/Tyrosine-protein kinase receptor UFO |
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| Ligand | BDBM50531863 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1921288 (CHEMBL4424133) |
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| IC50 | >200±n/a nM |
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| Citation |  Wang, Y; Xing, L; Ji, Y; Ye, J; Dai, Y; Gu, W; Ai, J; Song, Z Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core. Bioorg Med Chem Lett29:836-838 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcription factor ETV6/Tyrosine-protein kinase receptor UFO |
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| Name: | Transcription factor ETV6/Tyrosine-protein kinase receptor UFO |
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| Synonyms: | TEL/AXL |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1921288 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Tyrosine-protein kinase receptor UFO |
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| Synonyms: | AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 98316.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30530 |
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| Residue: | 894 |
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| Sequence: | MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
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| Component 2 |
| Name: | Transcription factor ETV6 |
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| Synonyms: | ETS translocation variant 6 | ETS-related protein Tel1 | ETV6 | ETV6_HUMAN | TEL | TEL1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53009.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107623 |
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| Residue: | 452 |
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| Sequence: | MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIY
WSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHI
LKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPM
ENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHRE
GKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRW
EDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFM
KTPDEIMSGRTDRLEHLESQELDEQIYQEDEC
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| BDBM50531863 |
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| n/a |
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| Name | BDBM50531863 |
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| Synonyms: | CHEMBL4592943 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H33N7O4 |
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| Mol. Mass. | 495.574 |
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| SMILES | CCc1nc(C(N)=O)c(Nc2ccc3OCC4CN(C)CCN4C(=O)c3c2)nc1NC1CCOCC1 |
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| Structure | 
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