| Reaction Details |
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 | Report a problem with these data |
| Target | Urease |
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| Ligand | BDBM50532145 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1921930 (CHEMBL4424775) |
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| IC50 | 2.2±n/a nM |
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| Citation |  Arshia, na; Begum, F; Almandil, NB; Lodhi, MA; Khan, KM; Hameed, A; Perveen, S Synthesis and urease inhibitory potential of benzophenone sulfonamide hybrid in vitro and in silico. Bioorg Med Chem27:1009-1022 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease |
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| Name: | Urease |
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| Synonyms: | UREA_CANEN | Urea amidohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 90746.20 |
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| Organism: | Canavalia ensiformis (Jack bean) (Horse bean) |
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| Description: | P07374 |
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| Residue: | 840 |
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| Sequence: | MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDDLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADKMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
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| BDBM50532145 |
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| n/a |
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| Name | BDBM50532145 |
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| Synonyms: | CHEMBL1549559 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N4O4S2 |
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| Mol. Mass. | 404.463 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1 |
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| Structure | 
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