| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 6 |
|---|
| Ligand | BDBM50532858 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1924031 (CHEMBL4426987) |
|---|
| IC50 | 1500±n/a nM |
|---|
| Citation |  Ferreira de Freitas, R; Eram, MS; Smil, D; Szewczyk, MM; Kennedy, S; Brown, PJ; Santhakumar, V; Barsyte-Lovejoy, D; Arrowsmith, CH; Vedadi, M; Schapira, M Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. J Med Chem59:6838-47 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein arginine N-methyltransferase 6 |
|---|
| Name: | Protein arginine N-methyltransferase 6 |
|---|
| Synonyms: | ANM6_HUMAN | HRMT1L6 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6 | Histone-arginine N-methyltransferase PRMT6 | PRMT6 | Protein arginine methyltransferase 6 (PRMT6) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 41928.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 375 |
|---|
| Sequence: | MSQPKKRKLESGGGGEGGEGTEEEDGAEREAALERPRRTKRERDQLYYECYSDVSVHEEM
IADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQA
REVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKE
GGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQG
LSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGE
SEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYK
VGDQEEKTKDFAMED
|
|
|
|---|
| BDBM50532858 |
|---|
| n/a |
|---|
| Name | BDBM50532858 |
|---|
| Synonyms: | CHEMBL4438506 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H17ClF2N2O2 |
|---|
| Mol. Mass. | 342.768 |
|---|
| SMILES | Cl.C[C@H](N)C(=O)NCc1ccc(Oc2ccccc2F)c(F)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
