| Reaction Details |
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 | Report a problem with these data |
| Target | Protein arginine N-methyltransferase 1 |
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| Ligand | BDBM50532859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1924041 (CHEMBL4426997) |
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| IC50 | >100000±n/a nM |
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| Citation |  Ferreira de Freitas, R; Eram, MS; Smil, D; Szewczyk, MM; Kennedy, S; Brown, PJ; Santhakumar, V; Barsyte-Lovejoy, D; Arrowsmith, CH; Vedadi, M; Schapira, M Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening. J Med Chem59:6838-47 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein arginine N-methyltransferase 1 |
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| Name: | Protein arginine N-methyltransferase 1 |
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| Synonyms: | 2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42451.61 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_100878 |
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| Residue: | 371 |
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| Sequence: | MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHF
GIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECS
SISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYA
RDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVV
DPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTG
FSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLC
ELSCSTDYRMR
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| BDBM50532859 |
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| n/a |
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| Name | BDBM50532859 |
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| Synonyms: | CHEMBL4436627 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25ClN2O2 |
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| Mol. Mass. | 348.867 |
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| SMILES | Cl.C[C@H](N)C(=O)NCc1ccc(Oc2cc(C)cc(C)c2)c(C)c1 |r| |
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| Structure | 
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