| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50533163 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1924593 (CHEMBL4427549) |
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| EC50 | 14±n/a nM |
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| Citation |  Dransfield, PJ; Pattaropong, V; Lai, S; Fu, Z; Kohn, TJ; Du, X; Cheng, A; Xiong, Y; Komorowski, R; Jin, L; Conn, M; Tien, E; DeWolf, WE; Hinklin, RJ; Aicher, TD; Kraser, CF; Boyd, SA; Voegtli, WC; Condroski, KR; Veniant-Ellison, M; Medina, JC; Houze, J; Coward, P Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394. ACS Med Chem Lett7:714-8 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50533163 |
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| n/a |
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| Name | BDBM50533163 |
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| Synonyms: | CHEMBL4528539 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F2N4O3 |
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| Mol. Mass. | 400.3787 |
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| SMILES | CCOc1ccc(cn1)-c1cnc(NC(=O)NC)cc1Oc1c(F)cccc1F |
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| Structure | 
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