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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 2 | ||
| Ligand | BDBM50533232 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1924757 (CHEMBL4427713) | ||
| IC50 | 2200±n/a nM | ||
| Citation |  Wang, H; Lawson, JD; Scorah, N; Kamran, R; Hixon, MS; Atienza, J; Dougan, DR; Sabat, M Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors. Bioorg Med Chem Lett26:4334-9 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 2 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 2 | ||
| Synonyms: | M3K2_HUMAN | MAP3K2 | MAPK/ERK kinase kinase 2 | MAPKKK2 | MEK kinase 2 | MEKK 2 | MEKK2 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 69751.14 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1473904 | ||
| Residue: | 619 | ||
| Sequence: |
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| BDBM50533232 | |||
| n/a | |||
| Name | BDBM50533232 | ||
| Synonyms: | CHEMBL4564126 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H15ClFN5O2 | ||
| Mol. Mass. | 411.817 | ||
| SMILES | Cc1cnc(cc1-n1c2ccncc2n(CC(N)=O)c1=O)-c1cc(Cl)ccc1F |(22.08,-22.62,;20.75,-23.4,;20.75,-24.95,;19.41,-25.72,;18.08,-24.95,;18.08,-23.4,;19.41,-22.63,;19.41,-21.09,;18.15,-20.2,;16.65,-20.52,;15.62,-19.38,;16.09,-17.91,;17.6,-17.59,;18.63,-18.73,;20.16,-18.73,;21.06,-17.48,;22.6,-17.63,;23.5,-16.39,;23.23,-19.04,;20.64,-20.19,;22.11,-20.66,;16.75,-25.72,;15.41,-24.94,;14.08,-25.71,;12.75,-24.94,;14.08,-27.25,;15.42,-28.02,;16.75,-27.25,;18.08,-28.02,)| | ||
| Structure | 
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