| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
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| Ligand | BDBM50089126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65272 |
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| IC50 | >10000±n/a nM |
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| Citation |  Revesz, L; Di Padova, FE; Buhl, T; Feifel, R; Gram, H; Hiestand, P; Manning, U; Zimmerlin, AG SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors. Bioorg Med Chem Lett10:1261-4 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 |
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| Name: | Mitogen-activated protein kinase 1 |
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| Synonyms: | ERT1 | Erk2 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK2) | MAP kinase 1 | MAP kinase 2 | MAP kinase ERK2 | MAPK 1 | MAPK 2 | MK01_MOUSE | Mapk | Mapk1 | Mitogen-activated protein kinase 2 | Prkm1 | p42 | p42-MAPK |
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| Type: | Protein |
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| Mol. Mass.: | 41278.65 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P63085 |
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| Residue: | 358 |
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| Sequence: | MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQ
TYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLS
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG
FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI
EVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM50089126 |
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| n/a |
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| Name | BDBM50089126 |
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| Synonyms: | 4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]-1-methyl-piperidin-4-ol | CHEMBL22978 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20FN3O2 |
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| Mol. Mass. | 353.3901 |
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| SMILES | CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 |
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| Structure | 
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