Found 224 hits with Last Name = 'manning' and Initial = 'u' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50175995
(CHEMBL199986 | N-(2,4-difluorophenyl)-3-(5-(3-(dim...)Show SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12)C#CCN(C)C Show InChI InChI=1S/C23H20F2N6O/c1-31(2)10-4-5-14-6-9-20(32-3)16(11-14)21-17-13-26-23(28-22(17)30-29-21)27-19-8-7-15(24)12-18(19)25/h6-9,11-13H,10H2,1-3H3,(H2,26,27,28,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176013
(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-b]p...)Show SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ccc12)C(=O)NC1CCOCC1 Show InChI InChI=1S/C25H23F2N5O3/c1-34-21-6-2-14(25(33)28-16-8-10-35-11-9-16)12-18(21)23-17-4-7-22(30-24(17)32-31-23)29-20-5-3-15(26)13-19(20)27/h2-7,12-13,16H,8-11H2,1H3,(H,28,33)(H2,29,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176003
(CHEMBL199993 | N-(2,4-difluorophenyl)-3-(2-methoxy...)Show SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12)C#CCN1CCN(C)CC1 Show InChI InChI=1S/C26H25F2N7O/c1-34-10-12-35(13-11-34)9-3-4-17-5-8-23(36-2)19(14-17)24-20-16-29-26(31-25(20)33-32-24)30-22-7-6-18(27)15-21(22)28/h5-8,14-16H,9-13H2,1-2H3,(H2,29,30,31,32,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148700
(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)Show SMILES C[C@H](Nc1nccc(n1)-c1nc([nH]c1-c1ccc(F)cc1)C1(O)CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C27H29FN6O/c1-18(19-6-4-3-5-7-19)30-26-29-15-12-22(31-26)24-23(20-8-10-21(28)11-9-20)32-25(33-24)27(35)13-16-34(2)17-14-27/h3-12,15,18,35H,13-14,16-17H2,1-2H3,(H,32,33)(H,29,30,31)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148699
(4-{2-(4-Fluoro-phenyl)-1-[2-((S)-1-phenyl-ethylami...)Show SMILES C[C@H](Nc1nccc(n1)-n1cc(nc1-c1ccc(F)cc1)C1(O)CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C27H29FN6O/c1-19(20-6-4-3-5-7-20)30-26-29-15-12-24(32-26)34-18-23(27(35)13-16-33(2)17-14-27)31-25(34)21-8-10-22(28)11-9-21/h3-12,15,18-19,35H,13-14,16-17H2,1-2H3,(H,29,30,32)/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50116031
(3,5,6-Trifluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4...)Show SMILES Nc1nc(F)c(F)c(-c2nc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)c1F Show InChI InChI=1S/C19H11F4N5/c20-11-3-1-9(2-4-11)15-16(10-5-7-25-8-6-10)27-19(26-15)12-13(21)17(23)28-18(24)14(12)22/h1-8H,(H2,24,28)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP |
Bioorg Med Chem Lett 12: 2109-12 (2002)
BindingDB Entry DOI: 10.7270/Q2610ZNX |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148703
(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)Show SMILES OC1(CCNCC1)c1nc(c(s1)-c1ccnc(NC2CCCCC2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H29FN4OS/c26-19-8-6-17(7-9-19)22-23(32-24(30-22)25(31)11-14-27-15-12-25)18-10-13-28-21(16-18)29-20-4-2-1-3-5-20/h6-10,13,16,20,27,31H,1-5,11-12,14-15H2,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50116037
(3,5-Difluoro-4-[5-(4-fluoro-phenyl)-4-pyridin-4-yl...)Show SMILES Nc1nc(N)c(F)c(-c2cc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)c1F Show InChI InChI=1S/C20H14F3N5/c21-12-3-1-11(2-4-12)18-13(10-5-7-26-8-6-10)9-14(27-18)15-16(22)19(24)28-20(25)17(15)23/h1-9,27H,(H4,24,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP |
Bioorg Med Chem Lett 12: 2109-12 (2002)
BindingDB Entry DOI: 10.7270/Q2610ZNX |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50175994
(CHEMBL371756 | N-cyclopentyl-3-(6-(2,4-difluorophe...)Show SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ccc12)C(=O)NC1CCCC1 Show InChI InChI=1S/C25H23F2N5O2/c1-34-21-10-6-14(25(33)28-16-4-2-3-5-16)12-18(21)23-17-8-11-22(30-24(17)32-31-23)29-20-9-7-15(26)13-19(20)27/h6-13,16H,2-5H2,1H3,(H,28,33)(H2,29,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148691
(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)Show SMILES C[C@H](Nc1cc(ccn1)-c1sc(nc1-c1ccc(F)cc1)C1(O)CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C28H29FN4OS/c1-19(20-6-4-3-5-7-20)31-24-18-22(12-15-30-24)26-25(21-8-10-23(29)11-9-21)32-27(35-26)28(34)13-16-33(2)17-14-28/h3-12,15,18-19,34H,13-14,16-17H2,1-2H3,(H,30,31)/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148702
(CHEMBL415712 | Cyclohexyl-{4-[2-(4-fluoro-phenyl)-...)Show SMILES Fc1ccc(cc1)-c1nc(cn1-c1ccnc(NC2CCCCC2)n1)C1CCNCC1 Show InChI InChI=1S/C24H29FN6/c25-19-8-6-18(7-9-19)23-29-21(17-10-13-26-14-11-17)16-31(23)22-12-15-27-24(30-22)28-20-4-2-1-3-5-20/h6-9,12,15-17,20,26H,1-5,10-11,13-14H2,(H,27,28,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50116038
(4-(4-Benzofuran-2-yl-5-pyridin-4-yl-1H-imidazol-2-...)Show SMILES Nc1nc(N)c(F)c(-c2nc(-c3cc4ccccc4o3)c([nH]2)-c2ccncc2)c1F Show InChI InChI=1S/C21H14F2N6O/c22-15-14(16(23)20(25)29-19(15)24)21-27-17(10-5-7-26-8-6-10)18(28-21)13-9-11-3-1-2-4-12(11)30-13/h1-9H,(H,27,28)(H4,24,25,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP |
Bioorg Med Chem Lett 12: 2109-12 (2002)
BindingDB Entry DOI: 10.7270/Q2610ZNX |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148696
(CHEMBL119952 | {4-[(S)-2-(4-Fluoro-phenyl)-5-(4-me...)Show SMILES C[C@H](Nc1nccc(n1)-n1c(nc2nc(ccc12)N1CCN(C)CC1)-c1ccc(F)cc1)c1ccccc1 Show InChI InChI=1S/C29H29FN8/c1-20(21-6-4-3-5-7-21)32-29-31-15-14-26(34-29)38-24-12-13-25(37-18-16-36(2)17-19-37)33-27(24)35-28(38)22-8-10-23(30)11-9-22/h3-15,20H,16-19H2,1-2H3,(H,31,32,34)/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50175998
(4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-...)Show SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)cnc12)C#CC(C)(C)O Show InChI InChI=1S/C23H19F2N5O2/c1-23(2,31)9-8-13-4-7-18(32-3)15(10-13)20-21-22(30-29-20)28-19(12-26-21)27-17-6-5-14(24)11-16(17)25/h4-7,10-12,31H,1-3H3,(H2,27,28,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148693
(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)Show SMILES C[C@H](Nc1cc(ccn1)-c1nc([nH]c1-c1ccc(F)cc1)C1(O)CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C28H30FN5O/c1-19(20-6-4-3-5-7-20)31-24-18-22(12-15-30-24)26-25(21-8-10-23(29)11-9-21)32-27(33-26)28(35)13-16-34(2)17-14-28/h3-12,15,18-19,35H,13-14,16-17H2,1-2H3,(H,30,31)(H,32,33)/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148698
(CHEMBL333899 | Cyclohexyl-{4-[4-piperidin-4-yl-2-(...)Show SMILES FC(F)(F)c1cccc(c1)-c1nc(cn1-c1ccnc(NC2CCCCC2)n1)C1CCNCC1 Show InChI InChI=1S/C25H29F3N6/c26-25(27,28)19-6-4-5-18(15-19)23-32-21(17-9-12-29-13-10-17)16-34(23)22-11-14-30-24(33-22)31-20-7-2-1-3-8-20/h4-6,11,14-17,20,29H,1-3,7-10,12-13H2,(H,30,31,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148695
(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)Show SMILES C[C@H](Nc1cc(ccn1)-c1oc(nc1-c1ccc(F)cc1)C1(O)CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C28H29FN4O2/c1-19(20-6-4-3-5-7-20)31-24-18-22(12-15-30-24)26-25(21-8-10-23(29)11-9-21)32-27(35-26)28(34)13-16-33(2)17-14-28/h3-12,15,18-19,34H,13-14,16-17H2,1-2H3,(H,30,31)/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176006
(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)Show SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)cnc12)C#CC(C)(C)N Show InChI InChI=1S/C23H20F2N6O/c1-23(2,26)9-8-13-4-7-18(32-3)15(10-13)20-21-22(31-30-20)29-19(12-27-21)28-17-6-5-14(24)11-16(17)25/h4-7,10-12H,26H2,1-3H3,(H2,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148697
(4-{4-(4-Fluoro-phenyl)-5-[2-((S)-1-phenyl-ethylami...)Show SMILES C[C@H](Nc1nccc(n1)-c1oc(nc1-c1ccc(F)cc1)C1(O)CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C27H28FN5O2/c1-18(19-6-4-3-5-7-19)30-26-29-15-12-22(31-26)24-23(20-8-10-21(28)11-9-20)32-25(35-24)27(34)13-16-33(2)17-14-27/h3-12,15,18,34H,13-14,16-17H2,1-2H3,(H,29,30,31)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176010
(CHEMBL199319 | N-(2,4-difluorophenyl)-3-(5-(3-(dim...)Show SMILES COc1ccc(CCCN(C)C)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12 Show InChI InChI=1S/C23H24F2N6O/c1-31(2)10-4-5-14-6-9-20(32-3)16(11-14)21-17-13-26-23(28-22(17)30-29-21)27-19-8-7-15(24)12-18(19)25/h6-9,11-13H,4-5,10H2,1-3H3,(H2,26,27,28,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176000
(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)Show SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12)C#CC(C)(C)N Show InChI InChI=1S/C23H20F2N6O/c1-23(2,26)9-8-13-4-7-19(32-3)15(10-13)20-16-12-27-22(29-21(16)31-30-20)28-18-6-5-14(24)11-17(18)25/h4-7,10-12H,26H2,1-3H3,(H2,27,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176005
(CHEMBL381457 | N-(2,4-difluorophenyl)-3-(2-methoxy...)Show SMILES COc1ccc(CCCN2CCN(C)CC2)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12 Show InChI InChI=1S/C26H29F2N7O/c1-34-10-12-35(13-11-34)9-3-4-17-5-8-23(36-2)19(14-17)24-20-16-29-26(31-25(20)33-32-24)30-22-7-6-18(27)15-21(22)28/h5-8,14-16H,3-4,9-13H2,1-2H3,(H2,29,30,31,32,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148690
(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)Show SMILES OC1(CCNCC1)c1nc(c(o1)-c1ccnc(NC2CCCCC2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H29FN4O2/c26-19-8-6-17(7-9-19)22-23(32-24(30-22)25(31)11-14-27-15-12-25)18-10-13-28-21(16-18)29-20-4-2-1-3-5-20/h6-10,13,16,20,27,31H,1-5,11-12,14-15H2,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148692
(CHEMBL120185 | Cyclopentyl-{4-[2-(4-fluoro-phenyl)...)Show SMILES CN1CCN(CC1)c1ccc2n(c(nc2n1)-c1ccc(F)cc1)-c1ccnc(NC2CCCC2)n1 Show InChI InChI=1S/C26H29FN8/c1-33-14-16-34(17-15-33)22-11-10-21-24(30-22)32-25(18-6-8-19(27)9-7-18)35(21)23-12-13-28-26(31-23)29-20-4-2-3-5-20/h6-13,20H,2-5,14-17H2,1H3,(H,28,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50116029
(3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...)Show SMILES Nc1nc(N)c(F)c(-c2nc(c([nH]2)-c2ccc(F)cc2)-c2ccncc2)c1F Show InChI InChI=1S/C19H13F3N6/c20-11-3-1-9(2-4-11)15-16(10-5-7-25-8-6-10)27-19(26-15)12-13(21)17(23)28-18(24)14(12)22/h1-8H,(H,26,27)(H4,23,24,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP |
Bioorg Med Chem Lett 12: 2109-12 (2002)
BindingDB Entry DOI: 10.7270/Q2610ZNX |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50404281
(CHEMBL2111784)Show SMILES C[C@H](Nc1cc(ccn1)-c1sc(nc1-c1ccc(F)cc1)C1CCN(C)CC1)c1ccccc1 Show InChI InChI=1S/C28H29FN4S/c1-19(20-6-4-3-5-7-20)31-25-18-23(12-15-30-25)27-26(21-8-10-24(29)11-9-21)32-28(34-27)22-13-16-33(2)17-14-22/h3-12,15,18-19,22H,13-14,16-17H2,1-2H3,(H,30,31)/t19-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50175999
(4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-...)Show SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12)C#CC(C)(C)O Show InChI InChI=1S/C23H19F2N5O2/c1-23(2,31)9-8-13-4-7-19(32-3)15(10-13)20-16-12-26-22(28-21(16)30-29-20)27-18-6-5-14(24)11-17(18)25/h4-7,10-12,31H,1-3H3,(H2,26,27,28,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089127
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-11(2-4-13)14-15(12-5-9-19-10-6-12)21-16(20-14)17(22)7-8-17/h1-6,9-10,22H,7-8H2,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176007
(3-(5-(3-amino-3-methylbut-1-ynyl)-2-methoxyphenyl)...)Show SMILES COc1ccc(cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ccc12)C#CC(C)(C)N Show InChI InChI=1S/C24H21F2N5O/c1-24(2,27)11-10-14-4-8-20(32-3)17(12-14)22-16-6-9-21(29-23(16)31-30-22)28-19-7-5-15(25)13-18(19)26/h4-9,12-13H,27H2,1-3H3,(H2,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176001
(4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-...)Show SMILES COc1ccc(CCC(C)(C)O)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)cnc12 Show InChI InChI=1S/C23H23F2N5O2/c1-23(2,31)9-8-13-4-7-18(32-3)15(10-13)20-21-22(30-29-20)28-19(12-26-21)27-17-6-5-14(24)11-16(17)25/h4-7,10-12,31H,8-9H2,1-3H3,(H2,27,28,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50148694
(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)Show SMILES CN1CCC(O)(CC1)c1cn(c(n1)-c1cccc(c1)C(F)(F)F)-c1ccnc(NC2CCCC2)n1 Show InChI InChI=1S/C25H29F3N6O/c1-33-13-10-24(35,11-14-33)20-16-34(21-9-12-29-23(32-21)30-19-7-2-3-8-19)22(31-20)17-5-4-6-18(15-17)25(26,27)28/h4-6,9,12,15-16,19,35H,2-3,7-8,10-11,13-14H2,1H3,(H,29,30,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176004
(3-(5-(3-amino-3-methylbutyl)-2-methoxyphenyl)-N-(2...)Show SMILES COc1ccc(CCC(C)(C)N)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)cnc12 Show InChI InChI=1S/C23H24F2N6O/c1-23(2,26)9-8-13-4-7-18(32-3)15(10-13)20-21-22(31-30-20)29-19(12-27-21)28-17-6-5-14(24)11-16(17)25/h4-7,10-12H,8-9,26H2,1-3H3,(H2,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human)) | BDBM50069336
(CHEMBL439120 | NELNLGRREE | NQLPpYNELNLGRREEpYDVLD)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O Show InChI InChI=1S/C106H166N30O43P2/c1-48(2)36-64(125-99(165)70(44-78(111)140)128-94(160)65(37-49(3)4)126-91(157)63(28-32-82(146)147)124-98(164)69(43-77(110)139)129-97(163)68(41-54-19-23-56(24-20-54)179-181(175,176)177)131-101(167)74-16-13-35-136(74)103(169)72(39-51(7)8)133-93(159)60(25-29-75(108)137)120-86(152)57(107)42-76(109)138)87(153)118-47-79(141)119-58(14-11-33-116-105(112)113)88(154)121-59(15-12-34-117-106(114)115)89(155)122-61(26-30-80(142)143)90(156)123-62(27-31-81(144)145)92(158)127-67(40-53-17-21-55(22-18-53)178-180(172,173)174)96(162)130-71(45-83(148)149)100(166)135-85(52(9)10)102(168)132-66(38-50(5)6)95(161)134-73(104(170)171)46-84(150)151/h17-24,48-52,57-74,85H,11-16,25-47,107H2,1-10H3,(H2,108,137)(H2,109,138)(H2,110,139)(H2,111,140)(H,118,153)(H,119,141)(H,120,152)(H,121,154)(H,122,155)(H,123,156)(H,124,164)(H,125,165)(H,126,157)(H,127,158)(H,128,160)(H,129,163)(H,130,162)(H,131,167)(H,132,168)(H,133,159)(H,134,161)(H,135,166)(H,142,143)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,170,171)(H4,112,113,116)(H4,114,115,117)(H2,172,173,174)(H2,175,176,177)/t57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,85-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Antagonistic activity against SH2 domain of Zeta-chain (TCR) associated protein kinase, ZAP-70 |
Bioorg Med Chem Lett 7: 2875-2878 (1997)
Article DOI: 10.1016/S0960-894X(97)10102-0 BindingDB Entry DOI: 10.7270/Q2HX1CPG |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human)) | BDBM50069336
(CHEMBL439120 | NELNLGRREE | NQLPpYNELNLGRREEpYDVLD)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O Show InChI InChI=1S/C106H166N30O43P2/c1-48(2)36-64(125-99(165)70(44-78(111)140)128-94(160)65(37-49(3)4)126-91(157)63(28-32-82(146)147)124-98(164)69(43-77(110)139)129-97(163)68(41-54-19-23-56(24-20-54)179-181(175,176)177)131-101(167)74-16-13-35-136(74)103(169)72(39-51(7)8)133-93(159)60(25-29-75(108)137)120-86(152)57(107)42-76(109)138)87(153)118-47-79(141)119-58(14-11-33-116-105(112)113)88(154)121-59(15-12-34-117-106(114)115)89(155)122-61(26-30-80(142)143)90(156)123-62(27-31-81(144)145)92(158)127-67(40-53-17-21-55(22-18-53)178-180(172,173)174)96(162)130-71(45-83(148)149)100(166)135-85(52(9)10)102(168)132-66(38-50(5)6)95(161)134-73(104(170)171)46-84(150)151/h17-24,48-52,57-74,85H,11-16,25-47,107H2,1-10H3,(H2,108,137)(H2,109,138)(H2,110,139)(H2,111,140)(H,118,153)(H,119,141)(H,120,152)(H,121,154)(H,122,155)(H,123,156)(H,124,164)(H,125,165)(H,126,157)(H,127,158)(H,128,160)(H,129,163)(H,130,162)(H,131,167)(H,132,168)(H,133,159)(H,134,161)(H,135,166)(H,142,143)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,170,171)(H4,112,113,116)(H4,114,115,117)(H2,172,173,174)(H2,175,176,177)/t57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,85-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Preclinical Research Novartis
Curated by ChEMBL
| Assay Description Inhibition of binding to human ZAP-70 SH2 domain |
Bioorg Med Chem Lett 8: 405-8 (1999)
BindingDB Entry DOI: 10.7270/Q2VT1R78 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50148690
(4-[5-(2-Cyclohexylamino-pyridin-4-yl)-4-(4-fluoro-...)Show SMILES OC1(CCNCC1)c1nc(c(o1)-c1ccnc(NC2CCCCC2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H29FN4O2/c26-19-8-6-17(7-9-19)22-23(32-24(30-22)25(31)11-14-27-15-12-25)18-10-13-28-21(16-18)29-20-4-2-1-3-5-20/h6-10,13,16,20,27,31H,1-5,11-12,14-15H2,(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of human c-Jun N-terminal kinase 2 |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176002
(3-(5-(3-amino-3-methylbutyl)-2-methoxyphenyl)-N-(2...)Show SMILES COc1ccc(CCC(C)(C)N)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ccc12 Show InChI InChI=1S/C24H25F2N5O/c1-24(2,27)11-10-14-4-8-20(32-3)17(12-14)22-16-6-9-21(29-23(16)31-30-22)28-19-7-5-15(25)13-18(19)26/h4-9,12-13H,10-11,27H2,1-3H3,(H2,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176008
(3-(5-(3-amino-3-methylbutyl)-2-methoxyphenyl)-N-(2...)Show SMILES COc1ccc(CCC(C)(C)N)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12 Show InChI InChI=1S/C23H24F2N6O/c1-23(2,26)9-8-13-4-7-19(32-3)15(10-13)20-16-12-27-22(29-21(16)31-30-20)28-18-6-5-14(24)11-17(18)25/h4-7,10-12H,8-9,26H2,1-3H3,(H2,27,28,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50148692
(CHEMBL120185 | Cyclopentyl-{4-[2-(4-fluoro-phenyl)...)Show SMILES CN1CCN(CC1)c1ccc2n(c(nc2n1)-c1ccc(F)cc1)-c1ccnc(NC2CCCC2)n1 Show InChI InChI=1S/C26H29FN8/c1-33-14-16-34(17-15-33)22-11-10-21-24(30-22)32-25(18-6-8-19(27)9-7-18)35(21)23-12-13-28-26(31-23)29-20-4-2-3-5-20/h6-13,20H,2-5,14-17H2,1H3,(H,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of human c-Jun N-terminal kinase 2 |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176009
(4-(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-...)Show SMILES COc1ccc(CCC(C)(C)O)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ncc12 Show InChI InChI=1S/C23H23F2N5O2/c1-23(2,31)9-8-13-4-7-19(32-3)15(10-13)20-16-12-26-22(28-21(16)30-29-20)27-18-6-5-14(24)11-17(18)25/h4-7,10-12,31H,8-9H2,1-3H3,(H2,26,27,28,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50176011
(3-(5-((cyclopentylamino)methyl)-2-methoxyphenyl)-N...)Show SMILES COc1ccc(CNC2CCCC2)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ccc12 Show InChI InChI=1S/C25H25F2N5O/c1-33-22-10-6-15(14-28-17-4-2-3-5-17)12-19(22)24-18-8-11-23(30-25(18)32-31-24)29-21-9-7-16(26)13-20(21)27/h6-13,17,28H,2-5,14H2,1H3,(H2,29,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089122
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H22FN3O/c22-17-7-5-15(6-8-17)18-19(16-9-13-23-14-10-16)25-20(24-18)21(26)11-3-1-2-4-12-21/h5-10,13-14,26H,1-4,11-12H2,(H,24,25) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089123
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C19H18FN3O/c20-15-5-3-13(4-6-15)16-17(14-7-11-21-12-8-14)23-18(22-16)19(24)9-1-2-10-19/h3-8,11-12,24H,1-2,9-10H2,(H,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089125
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)Show SMILES CN1CCC(O)(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H21FN4O/c1-25-12-8-20(26,9-13-25)19-23-17(14-2-4-16(21)5-3-14)18(24-19)15-6-10-22-11-7-15/h2-7,10-11,26H,8-9,12-13H2,1H3,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50116025
(2,3,5,6-Tetrafluoro-4-[4-(4-fluoro-phenyl)-5-pyrid...)Show SMILES Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1c(F)c(F)nc(F)c1F Show InChI InChI=1S/C19H9F5N4/c20-11-3-1-9(2-4-11)15-16(10-5-7-25-8-6-10)27-19(26-15)12-13(21)17(23)28-18(24)14(12)22/h1-8H,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP |
Bioorg Med Chem Lett 12: 2109-12 (2002)
BindingDB Entry DOI: 10.7270/Q2610ZNX |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089125
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)Show SMILES CN1CCC(O)(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H21FN4O/c1-25-12-8-20(26,9-13-25)19-23-17(14-2-4-16(21)5-3-14)18(24-19)15-6-10-22-11-7-15/h2-7,10-11,26H,8-9,12-13H2,1H3,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha. |
Bioorg Med Chem Lett 14: 3595-9 (2004)
Article DOI: 10.1016/j.bmcl.2004.03.106 BindingDB Entry DOI: 10.7270/Q2V69J2C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50175996
(CHEMBL200017 | N-(2,4-difluorophenyl)-3-(2-methoxy...)Show SMILES COc1ccc(CNC2CCOCC2)cc1-c1[nH]nc2nc(Nc3ccc(F)cc3F)ccc12 Show InChI InChI=1S/C25H25F2N5O2/c1-33-22-6-2-15(14-28-17-8-10-34-11-9-17)12-19(22)24-18-4-7-23(30-25(18)32-31-24)29-21-5-3-16(26)13-20(21)27/h2-7,12-13,17,28H,8-11,14H2,1H3,(H2,29,30,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibitory activity against murine p38alpha MAPK |
Bioorg Med Chem Lett 16: 262-6 (2005)
Article DOI: 10.1016/j.bmcl.2005.10.015 BindingDB Entry DOI: 10.7270/Q2DJ5F6T |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089130
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H20FN3O/c21-16-6-4-14(5-7-16)17-18(15-8-12-22-13-9-15)24-19(23-17)20(25)10-2-1-3-11-20/h4-9,12-13,25H,1-3,10-11H2,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089124
(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-...)Show SMILES CN1CCC(O)(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H22FN3O/c1-25-12-8-21(26,9-13-25)19-14-18(15-6-10-23-11-7-15)20(24-19)16-2-4-17(22)5-3-16/h2-7,10-11,14,24,26H,8-9,12-13H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50116028
(3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...)Show SMILES Nc1nc(N)c(F)c(-c2nc(c(s2)-c2ccncc2)-c2ccc(F)cc2)c1F Show InChI InChI=1S/C19H12F3N5S/c20-11-3-1-9(2-4-11)15-16(10-5-7-25-8-6-10)28-19(26-15)12-13(21)17(23)27-18(24)14(12)22/h1-8H,(H4,23,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATP |
Bioorg Med Chem Lett 12: 2109-12 (2002)
BindingDB Entry DOI: 10.7270/Q2610ZNX |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089132
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C18H16FN3O/c19-14-4-2-12(3-5-14)15-16(13-6-10-20-11-7-13)22-17(21-15)18(23)8-1-9-18/h2-7,10-11,23H,1,8-9H2,(H,21,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this Ligand-Target Pair | |