Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50148698 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_124496 |
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IC50 | 8±n/a nM |
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Citation | Revesz, L; Blum, E; Di Padova, FE; Buhl, T; Feifel, R; Gram, H; Hiestand, P; Manning, U; Rucklin, G Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis. Bioorg Med Chem Lett14:3595-9 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha |
Type: | Enzyme |
Mol. Mass.: | 41281.22 |
Organism: | Mus musculus (mouse) |
Description: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography. |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50148698 |
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n/a |
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Name | BDBM50148698 |
Synonyms: | CHEMBL333899 | Cyclohexyl-{4-[4-piperidin-4-yl-2-(3-trifluoromethyl-phenyl)-5H-imidazol-1-yl]-pyrimidin-2-yl}-amine |
Type | Small organic molecule |
Emp. Form. | C25H29F3N6 |
Mol. Mass. | 470.5332 |
SMILES | FC(F)(F)c1cccc(c1)-c1nc(cn1-c1ccnc(NC2CCCCC2)n1)C1CCNCC1 |
Structure |
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